Pedrosa made his MotoGP debut in 2006 with Honda and raced his entire premier class career with the Japanese marque, winning 36 races and finishing runner-up in the standings on three occasions.
The double 250cc world champion and one-time 125cc title winner retired from MotoGP at the end of the 2018 season and took up a role as KTM’s official test rider.
Pedrosa’s work as test rider has been instrumental in propelling KTM to the front of the grid in MotoGP, with his efforts baring fruit last year.
Brad Binder took KTM’s first ever MotoGP win at the Czech Grand Prix in 2020 just three races into his rookie season, before Miguel Oliveira added a second to its tally at the Styrian GP.
Oliveira sealed KTM’s third win in the season finale in Portugal and took its fourth in this year’s Catalan GP.
KTM is yet to confirm Pedrosa’s Misano wildcard, but has been hinting at it for some time.
As well as Pedrosa, two other wildcards are set to start the San Marino GP, with Honda fielding its test rider Stefan Bradl and Ducati giving Michele Pirro an outing on home soil.
Wildcards have been reinstated for the 2021 season after they were scrapped in 2020 owing to the COVID-19 pandemic.
KTM’s 2021 season has been a mixed affair, with Oliveira and teammate Brad Binder struggling in the early races – its issues largely a result of the softer front tyre allocation Michelin has brought to 2021.